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KMID : 0605620060130010032
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Journal of Korean Society of Biological Psychiatry
2006 Volume.13 No. 1 p.32 ~ p.37
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The Change of Interleukin-12 and Transforming Growth Factor-beta1 Level in Manic Patients after Treatment
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Choi Hyun-Seok
Kim Yong-Ku
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Abstract
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Background:Several studies have suggested that alterations of cytokine level could be related to the pathophysiology of bipolar disorder. In this study, we measured plasma level of Interleukin-12(IL-12), a pro-inflammatory cytokine and transforming growth factor-beta1(TGF-beta1), an anti-inflammatory cytokine before and after treatment in acute manic patients.
methods:The plasma concentrations of IL-12 and TGF-beta1 were measured using quantitative ELISA in 18 bipolar disorder patients and 25 normal controls at admission and 6 weeks later. The psychopathology was measured by Brief Psychiatric Rating Scale(BPRS) and Young Mania Rating Scale(YMRS).
Results:IL-12 levels were significantly higher in bipolar manic patients than in controls before treatment. Following the 6-week treatment, the IL-12 level was decreased than before treatment, but sustained still higher level than normal control. TGF-beta1 level was not significant different between manic patients and normal controls before treatment, but was increased after treatment comparing with before treatment in bipolar patients. The ratio of IL-12 and TGF-beta1 was significantly decreased after treatment.
Conclusions:Cytokine abnormalities in bipolar disorder might be involved in the pathophysiology of the illness. It is possible that TGF-beta1 plays an important role in the regulation of immunological imbalance in bipolar disorder.
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KEYWORD
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Cytokine, Interleukin, TGF, Bipolar disorder
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